Game runs flawlessly after first few minutes - presumed vulkan shaders loading. Biggest problem was getting TacSpeak to run with this in wine. This is doable! Both TacSpeak and the game needs to be running in the same wine prefix, input needs to be set to voice activation and all Visual C++ runtime versions need to be installed. Here follows a breakdown of how I did it:

In the settings file for tacspeak change input to 'None'. This ensures the keyboard is no longer required for voice inputs.

Via winetricks/protontricks install Visual C++ runtime:
-- select default wineprefix (the one that's running the game)
-- install windows DLL or component
-- install all versions of Visual C++ libraries (all vcrun options)
-- launch both the game and tacspeak in the same container using something like lutris or protontricks

Now game and voice input works flawlessly.