The game works perfectly well out of the box, i didn't had to do any modification and i was able to run the game normaly even with mods, but there is a weid bug that happens when you alt+tab to another window, the game comes out of fullscreen, stop recognizing your controller and the only way to fix it is to close the game and open again, i fix this issue using gamescope but that made a new problem appear, with gamescope the game freezes for some odd reason, then i fix the freezing adding "PROTON_USE_WINED3D=1", after that i had no issues at all.