Not work if you launch the game directly with steam, try with an external command shell (or with lutris) i enable DXVK (1.2.2), Esync and enable pulseaudio low latency option. You cannot launch the "Initial Settings.exe" so for change the option you can go in UserData/setup.xml and change the quality and size screen. Every else work perfectly, you can also install the official patch, you just need wine+.net or mono.