Tested both GE-Proton10-3 and Steam Proton 9.0-4, the first start takes a bit, both work flawless without audio, input or save issues.

The game runs out of the box for me, without launch options, it runs at the same fps as in Windows 11. On my system I get 60fps in the sewers, around 40fps outside and in some interiors where a lot of entities are loaded, it drops below 15fps (Tiber Septim Hotel top floor during The Lonely Wanderer quest).

I use Linux Mint 22, vanilla, only changed a wallpaper and downloaded ProtonGE. No kernel or tweaks on the distro.

I run the game at low details, Resolution Scale at 50%, V-Sync off, fps capped at 60, View distance on High, Textures on High, Shadows on Medium, Reflection on Medium. Native 1080p resolution, no FSR and Antialiasing TAA.