I bought the game on GOG and installed it using Heroic.

Tried many many times running the game through Heroic, even tried some launcher options and other Proton-GE versions, but the game would either not even start or close itself after showing the first few logos.

I finally was able to play the game when I went to the folder where the game was installed and executed the "Darksiders2.exe" file directly. I believe that in this case the system automatically uses Wine to execute the game. That was the only way i found to play the game, was not able to do so using any other option in Heroic.

My computer was able to run the game normally (~144 fps), however I don't know if a lower end pc would be able to run the game this smoothly, since it is apparently not using proton.

Obs: You can also add this .exe file into steam as a non steam game, just make sure to not force any compatibility layer.