I first tried running this game after initial install but I couldn’t play the game due to too frequent occurrence of a Pure Virtual Function errors. Renamed OpenAL32.dll from ~/.steam/steam/steamapps/common/Mass Effect/Binariesto to OpenAL32.dll.bakup (fixes borked sound). Used PROTON_FORCE_LARGE_ADDRESS_AWARE=1 PROTON_NO_ESYNC=1 PROTON_USE_D9VK=1 %command% in Launch Options as seen used by others in the previous reports. So far no no crashes, no errors at all. Thanks to all the reports I am playing this game now flawlessly.