If using a controller do not use the Key Settings menu. After opening it and selecting an input the game waits for a new kbm input to rebind; all controller buttons give an error noise at this point and there is no way to cancel or close the menu without connecting a kbm or force-closing the game and losing any unsaved progress.

With all standard Proton tools I tried (7, 8, Hotfix, and Experimental as of January '24), the prerendered cutscene about 9-10 minutes into tutorial section (after leaving Cres's clinic) hangs on black screen indefinitely while music continues. Game must be force-quit, losing all progress.