Game works out of box with standard proton or GE, but cutscenes don't work (hangs with GE). They can be disabled from the config tool in order to bypass them. Cutscenes require a mix of protontricks and installed libraries.

With protontricks:

protontricks 223810 winecfg -> add winegstreamer and edit -> disable

protontricks 223810 amstream quartz

Then you have to enable sudo and initialize pacman to install some libraries.

sudo pacman -S gstreamer lib32gstreamer

Protontricks commands will also have to be used for Ys 2 (223810). Afterwards, cutscenes will work.

Gamepad controls may also be screwed up, but should work after just opening up the config tool (set the resolution to 1200x800) while you're there.