Changed Cities.x64 -> Cities_Loader.sh in launcher-settings.json for Patch Loader Mod.

Skyve can be made work by running it with Lutris and Wine-GE:

1. Install Skyve and its dependencies
2. Start Cities: Skylines
3. Click on the "SKYVE" button to open the executable's directory and save the executable's path for later
4. Close Cities: Skylines
5. Lutris > Plus in top-left corner > "Add locally installed game"
6. Game info > Name: Cities: Skylines Skyve
7. Game info > Runner: Wine (Runs Windows games)
8. Game Options > Executable: Skyve.exe's path
9. Game Options > Working directory: Skyve.exe's parent directory's path
10. Game Options > Wine prefix: Make a directory. E.g. ~/Games/CitiesSkylinesSkyveWineprefix
11. Make sure Runner options > Wine version is set to Wine-GE
12. Optionally disable some unnecessary additional options (like anticheats or DXVK) in Runner options
13. Launch Skyve!

As some other answers have stated, you might have to add SDL_VIDEODRIVER=x11 to your launch options if you set SDL_VIDEODRIVER=wayland somewhere else (e.g. window manager/compositor config). That configuration option breaks apps with old SDL versions like Source games. I don't set SDL_VIDEODRIVER=wayland so I don't have to think about this.