Had to install msvcirt.dll, as others have mentioned. Can't get gamepad controller to work. Biggest upset was erratic mouse control that was solved by 1) Running winecfg and enabling Virtual Desktop to match my desktop's resolution. 2) Installing the Killer App Mod and then setting Tron 2.0 to use my desktop's resolution.

There is something wrong with this game's mouse warping that is not solved by playing with Mouse Warp Override.