Triple monitor setup with the ultrawide primary - In fullscreen mode I can pause the game ([ESC]) and interact with other monitors, but can't interact with anything else on the primary monitor.

Three times in 30 hours the game has gotten stuck on a loading screen (usually the SCRAPPING SHIP splash screen). Because the game frequently autosaves, this hasn't been an issue.

Several other times, I have found that when the system goes to sleep while playing (and not paused, AFAICR) the game window is black and unresponsive when the computer is woken up. Closing the game from Steam or system is necesary.