From Modprog: run protontricks 3910 winecfg to show the winecfg. Under graphic disable capturing the cursor in fullscreen mode.

From Donut_Zombie: 1.from steam, right click on civ 3, and go to manage -> browse local files go into the Conquests folder, and edit the conquests.ini file with a text editor; add these two lines: KeepRes=1 PlayIntro=0 2.go up a level into (...)/steam/steamapps/common , then (...)/steam/steamapps/common/Proton 5.0/dist/lib/wine, rename gdi32.dll.so to gdi32.dll.so.bak 3.download the patched file into this directory. Right click on the file explorer and click 'Open in terminal'. copy and execute: curl 'https://bugs.winehq.org/attachment.cgi?id=69209' > gdi32.dll.so

This will not fix sound issue but it fixed the crashing for me.