Audio doesn't play (other than in the intro movies) when my audio interface is using a certain profile with Pipewire/wireplumber. But, changing the profile via pavucontrol fixed it. I've never had this problem with any other program.

I don't use WASD and occasionally my custom "strafe right" key would stop doing anything. Sometimes restarting the game would fix it, sometimes it wouldn't. I don't see any potential correlations with anything. Weirdly, even while my custom bind wasn't working, restoring the default and using that key worked fine, but rebinding it back to what I want broke it again. The key definitely isn't the problem, as I could input the key into other programs while the game was ignoring its inputs. Didn't test this on Windows, so this issue might be present on both platforms.