PoE patch 3.21.2+ needs a file named ".drirc" with the following content in the linux users' home directory or the game won't start:

<driconf>
    <device>
        <application name="Path of Exile" executable="PathOfExile_x64Steam.exe">
            <option name="vk_x11_override_min_image_count" value="2" />
        </application>
        <application name="Path of Exile" executable="PathOfExileSteam.exe">
            <option name="vk_x11_override_min_image_count" value="2" />
        </application>
    </device>
</driconf>