

"Play 32-bit" from launcher selection
Could be difficult to read, but I found it to be fine
Game is obveously intended to be played using mouse - tutorial prompts for key presses, but can be guessed around.
Crash on Launch if chosen "Play Himeko Sutori" launcher option - choosing "Play 32-bit" works fine.
Very minor Tinkering, as it's only a launch option when you try to open the game.
64 bit .exe doesn't work

Fails to start
Tried various proton versions, tried 32bit prefix. Nothing works.

32 bit wine prefix

Crashes on start. Final log entry:
[ERROR] FATAL UNHANDLED EXCEPTION: System.TypeLoadException: Could not load type of field ':__m2mep@?ToColor@CLRTools@@$$FYM?AVColor@Media@Windows@System@@AEBVFColor@@@Z' (2668) due to: Could not load file or assembly 'PresentationCore, Version=4.0.0.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35' or one of its dependencies.