In "Rise of Eros: 2346550", I ran winecfg to add RiseOfEros.exe and UnityCrashHandler64.exe and set them to "Windows Version: Windows 10". I next tried checking win10 in under "Change settings". Rise of Eros is playable for a few minutes, then just locks up, and so does it's crash handler (UnityCrashHandler64.exe) especially during cutscene videos and character summons which forces me to shutdown the game through Steam.

On a side note, I did try Steam Launch options "PROTON_NO_ESYNC PROTON_NO_FSYNC %command%" before trying "PROTON_FORCE_LARGE_ADDRESS_AWARE %command%". Both times, Rise of Eros refused to even start at all. It wasn't until I removed all launch commands did the game start. However, the game crashes just a few minutes after gameplay, especially during cutscene movies and character summons.